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Cases of alleged research misconduct are investigated by the Commission for Research Integrity (CRI). The CRI is an independent committee within LARI and comprised of renowned international research integrity experts from diverse disciplinary and geographical backgrounds. Currently, the CRI has seven members. All members of the CRI are from outside Luxembourg and not affiliated with any LARI member organization. Investigations are undertaken without any interference from LARI member organizations, i.e., the CRI proceeds in full independence and does not receive any directives or orders.

Cases are primarily investigated by two members of the CRI, referred to as first reader and second reader. Usually, the CRI members with most subject area expertise in a given case are appointed as first and second reader. However, all key decisions are made by the entire committee. More information on how the CRI operates is available in the Rules of Procedure for the National Commission for Research Integrity.

If conducting a thorough investigation presupposes subject area expertise not covered by CRI members, the CRI may involve external experts who are subject to the same selection criteria and are bound by the same confidentiality rules as CRI members.